5 epigenetic regulation of the immune response

Epigenetic regulation of normal and malignant hematopoiesis

Ngày tải lên : 05/09/2015, 11:25

... expressed, the leukemogenic potential of these fusion proteins is unclear Irrespective of the exact Oncogene mechanism, the expression of these fusion proteins is associated with the loss of monoacetylated ... rearrangement of the immunoglobulin heavy chain (Su et al., 2003) Since EZH2 requires the presence of the other PRC2, and members for HMT activity, it is not surprising that dysregulation of other PRC ... repression of speciﬁc target genes The interaction of PML-RARa with PRC2/3/4 was through the PML portion of the fusion, and wild-type PML but not RARa, was capable of binding PRC2/3/4 Taken together, these...

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Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps

Ngày tải lên : 09/08/2014, 08:22

... approved the final manuscript Acknowledgements cells Although the nature and origin of the 11β-HSD2expressing cells in RA is clearly of importance, it still appears that the normal response of synovial ... by the recent characterization of the adipocyte-specific transgenic mouse for 11βHSD1, the phenotype of which is profound obesity [36] In addition to this effect on mature cell function, the ... severity of inflammatory arthritis For example, local metabolism of prednisone/prednisolone may partly explain the early dramatic response to therapy that occurs as a result of increased generation of...

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báo cáo khoa học: "CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation" potx

Ngày tải lên : 10/08/2014, 22:21

... the criteria of Weber et al [13] the CD7 exon region contains a subthreshold CpG island (inter- Epigenetic regulation of CD7 Study of T-cell lines confirmed that CD7 repression can occur in the ... for repression of CD7 besides promoter methylation Methods Human cell lines The continuous cell lines were either taken from the stock of the cell bank (DSMZ - German Collection of Microorganisms ... To confirm the methylation status of the CD7 promoter, DNA of cell lines was bisulfite converted according to the manufacturer's instructions (Qiagen) Subsequently, amplification of the CD7 exon...

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11 cb Exercises of Unit 12- 1

Ngày tải lên : 28/07/2013, 01:27

... robber used to kill the man http://thuyquynh.violet.vn/ C The knife which the robber uses for kill the man is on the table D The knife used to kill the man the robber put it on the table 48 houses/situate/ ... There is a cathedral and a university There are five bridges over the River Tyne, which link Newcastle to the next town, Gateshead, where there is one of the biggest shopping centers in the world ... has one of _ in the world a the largest rivers b .the most important shipbuilding industries c .the most beautiful countrysides d the biggest shopping centers 34 According to the passage, the writer...

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11 cb Exercises of Unit 12- 2

Ngày tải lên : 28/07/2013, 01:27

... regulating from the time of the Ancient Olympics A B up to the present century C D The tourism is the activity of travel for the purpose of recreation and business, A B and the provision of services ... in the world’s climate Which of the following is the best title for the passage? a How Ecosystems Work Better b The Loss of Biodiversity c The Variety of Species d Natural Mechanisms Which of the ... miles off the southeastern coast of Massachusetts ………………., a popular summer resort a lies the island of Martha’s Vineyard b the island of Martha’s Vineyard lies there c does lie the island of Martha’s...

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Regulation of S Phase

Ngày tải lên : 25/10/2013, 21:20

... could initiate from the intergenic region in the absence of the major sites, and even in the absence of 90% of the region (Mesner et al., 2003) These studies indicate the regions of potential origin ... initiation (Fig 1) The chromatin loading of MCM2-7 depends on the loading of Cdt1 and Cdc6, which in turn depend on the loading of ORC This step- Fig Regulation of the pre-RC The pre-RC functions ... also co-dependent with Cdc45, Dpb11, and Sld3; binding of any of Regulation of S Phase 47 these proteins depended on the presence of the others (Kubota et al., 2003; Takayama et al., 2003) Although...

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Regulation of navigation and vessel-source pollution in the Northern Sea Route - Article 234 and state practice

Ngày tải lên : 01/11/2013, 09:20

... accompaniment of the CCGS John A 40 41 42 43 See Arts and 10 of the NSR Regulations; Arts 14 and 15 of the Economic Zone Edict; Arts and 15 of the Environmental Edict; and Art 11 of the Decree of the Council ... 7(4) of the NSR Regulations; Art 14 of the Economic Zone Edict; and Art of the Environmental Edict Art 236 of the LOS Convention See Churchill and Lowe, The Law of the Sea, p 260 Nowhere in the ... and pollution in the Northern Sea Route 233 might well open the way for full application of the OPA in the EEZ of the USA The USA claims that the environmental provisions of the LOS Convention...

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Chapter 11 the cost of capital

Ngày tải lên : 16/12/2013, 14:57

... next dollar of total new financing  Is an increasing function of the level of total new financing  The ‘break point’ is the level of total new financing at which the cost of one of the financing ... • Understand the cost of capital and the specific sources of capital associated with the cost of capital • Determine the cost of debt and preference share capital • Calculate cost of ordinary ... edition Cost Of Preference Share Capital Duchess Limited is considering the issue of 12% preference shares with an issue price of $100 per share The costs of issuing and marketing the shares, the flotation...

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Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx

Ngày tải lên : 14/02/2014, 19:20

... sustained activation of the ERK1 ⁄ pathway [20] Furthermore, the induction of miR-34a depends on the activation of ERK1 ⁄ in K562 cells [21,22] We have demonstrated that the activation of MEK ⁄ ERK signaling ... recruitment of the R-smads stimulates the production of these miRNAs and thus represses the expression of their target genes TGF-b signaling is known to be involved in the epithelial–mesenchymal ... by the activation of ERK1 ⁄ and enhances the activity of ERK1 ⁄ by repressing negative regulators of the ERK ⁄ MAPK signaling pathway Some other miRNAs are also reported to be induced by the...

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Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc

Ngày tải lên : 14/02/2014, 22:20

... They induce the permeabilization of the mitochondrial membrane with the release of cytochrome c and the formation of the apoptosome [38] The major pro-apoptotic protein Bax exists mainly in the ... particular emphasis on the induction of DNA fragmentation, which is one of the most typical characteristics of apoptosis Regulators of DNA fragmentation One of the terminal processes of apoptosis is ... dephosphorylation of these sites Ser70 is the major physiological phosphorylation site for the survival function of Bcl-2 [82] The pro-apoptotic Bcl-2 proteins relocate to the surface of mitochondria...

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Tài liệu Regulation of cancer cell metabolism docx

Ngày tải lên : 15/02/2014, 04:20

... of sCO2, which is required for the assembly of the cytochrome c oxidase complex of the electron transport chain61 Thus, the loss of p53 might also be a major force behind the acquisition of the ... phenotype of tumour cells and influence tumour progression129 Response to hypoxia The response to hypoxia is the best studied of tumour cell stress responses owing to the wellknown effects of hypoxia ... during the cellular response to low oxygen conditions They are heterodimers that are composed of the constitutively expressed HIF1β (also known as ArnT) subunit, and either the HIF1α or the HIF2α...

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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

Ngày tải lên : 16/02/2014, 09:20

... promoters, mutation of the CHR leads to a more pronounced deregulation than the alteration of the CDE [40] Another gene tested for its cell cycle regulation is the cellular inhibitor of apoptosis protein ... However, as in most other CDE ⁄ CHR promoters, mutation of the CHR results in a smaller remaining cell cycle -regulation than alteration of the CDE [37] Interestingly, the core of the human Tome-1 ... Moreover, orientation of the CDE ⁄ CHR in the general context of a promoter appears to be relevant because inversion of the site in the human Cdc25C promoter resulted in a deregulation of cell cycle-dependent...

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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

Ngày tải lên : 16/02/2014, 09:20

... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits ... regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have been performed for AP-2a Up to now, there have been ... further analyze their interactions with AP-2 and the functional role of these in chondrocytes Furthermore, it is speculated that in melanoma, where AP-2a acts as a tumor suppressor, the loss of...

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Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc

Ngày tải lên : 18/02/2014, 04:20

... In accordance with the fundamental role of HSF1 in the heat shock response, the requirement of HSF1 and HSF4 in development of the lens and olfactory epithelium is limited to the postnatal period, ... altered [88] These results shed light on the regulatory mechanisms steering the developmental expression pattern of HSF2, and they also provide the ﬁrst example of involvement of miRNAs in the HSF ... development of the lens and maintenance of the olfactory epithelium [102] The ﬁrst evidence for a developmental function of HSF4 was provided by population genetic studies where mutations of the Hsf4...

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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

Ngày tải lên : 18/02/2014, 08:20

... into the potential biologically relevant role of miR-27 in the regulation of adipose tissue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice The 2352 ... differentiation Taken together, these results illustrate a critical and speciﬁc role of miR-27 in the regulation of adipogenic differentiation miR-27 prevents the induction of PPARc and C ⁄ EBPa ... involved in the regulation of miR-27 expression Our data suggest that the miR-27 gene family is potentially an important class of negative regulators of adipogenesis and may play a role in the regulation...

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Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx

Ngày tải lên : 18/02/2014, 11:20

... weights of 161.8, 28.2 and 13.2 kDa, respectively Regulation of cathepsin B activity The formation of the cathepsin B ⁄ cystatin C complex was seen as a shift of the elution peak of cathepsin ... conformational changes of the active site of cathepsin B, the results obtained in the present study provide a speciﬁc mechanism for the regulation of the activity of cathepsin B, which can be ... which the N-terminus of the inhibitor ﬁrst binds to the enzyme, displacing the occluding loop, followed by the 4740 binding of another two loops of the inhibitor [24] Besides protein inhibitors, the...

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Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx

Ngày tải lên : 18/02/2014, 14:20

... observed in any of the EREs, irrespective of the absence and presence of E2 Binding of ERa and ERb was increased in both ERE1 and ERE2 of the HOXC13 promoter (Fig 5A, lanes 1–4) The levels of E2-induced ... linked to the basal transcriptional regulation of the gene Furthermore, we also observed that the recruitment of MLL2 is induced by E2 at both ERE1 and ERE2 However, the recruitment of other MLLs ... Interestingly, the kinetics of E2-dependent binding of ERa and ERb to both ERE1 and ERE2 are different The binding of ERa is very low in the absence of E2, and is signiﬁcantly enhanced in the presence of...

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Tài liệu Báo cáo khoa học: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme ppt

Ngày tải lên : 18/02/2014, 16:20

... in the main chain of the subunit, or in the interaction of subunits within the trimer that linked the conformation of residues 120–125 to the position of the active site lip and closure of the ... mechanism of regulation that generates the apparently attractive feature of an increase in both S0.5 and the sigmoidity of the saturation curve for dCTP in response to the binding of dTTP to the enzyme ... observation is that due to the proximity of residues 120–125 from each subunit in the centre of the trimer, the side chains of Val122 of one subunit and Thr123 of the neighbouring subunit are...

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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

Ngày tải lên : 18/02/2014, 16:20

... trafﬁcking of the CD95 from inside the hepatocyte to the plasma membrane [39], which depends on a ROS-mediated tyrosine phosphorylation of the epidermal growth factor (EGF)-receptor, the association of ... apoptosis include activation of the protein kinase B survival pathway [31], p53 activation [32], induction of the serum- and glucocorticoidinducible kinase Sgk [33], expression of the heat shock protein ... association of CD95 with the EGF-receptor, and phosphorylation of CD95 on Tyr232 and Tyr291 by the EGF-receptor tyrosine kinase activity [15] Although the appearance of CD95 at the plasma membrane...

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